CDDO - C31H41NO4 - Bertin Bioreagent

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CDDO

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Cat No: 81035

Biochemicals - Ox Stress Reagents

CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM.{6806} By suppressing reactive oxygen and nitrogen sp...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid

Correlated keywords:

Nrf2 antioxidant ARE Keap1 oxidative stress inflammations cancers apoptosis inducers inhibitors inhibits inhibitions iNOS COX-2 COX2 ROS RNS heme oxygenase-1 oxygenase eotaxins eotaxin-1 PPARgamma PPAR.gamma. PPARg PPAR-gamma PPAR-.gamma. PPAR-g PPAR? PPAR-? oleanane triterpenoid cellular nitric oxide INF? INF-? INF-gamma INF-.gamma. INF-g INFg INF.gamma. INFgamma ROS/RNS peroxisome proliferator activated receptor RTA401 RTA-401

Product Overview:
CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM.{6806} By suppressing reactive oxygen and nitrogen species (ROS/RNS) formation, it promotes the cellular control of ROS/RNS levels that would lead to DNA damage associated with tumorigenesis.{21759} In various cancer cell lines, CDDO has been shown to specifically inhibit proliferation and induce apoptosis.{21759} Mechanism studies revealed that CDDO is a ligand for peroxisome proliferator-activated receptor γ, and also that it induces genes regulated by Nrf2, including heme oxygenase-1 and eotaxin-1, which play a role in antioxidant response element signaling activity.{21764,21756,21754}

Size	1 mg
Shipping	dry ice
CAS Number	218600-44-3
Molecular Formula	C₃₁H₄₁NO₄
SMILES	N#CC1=C[C@@]2(C)[C@](CC[C@]([C@@]3(C)[C@@]4([H])C5[C@@](CCC(C)(C)C5)(C(O)=O)CC3)(C)C2=CC4=O)([H])C(C)(C)C1=O
Molecular Weight	491,7
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2912.49
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.