Thioarginine (hydrobromide)

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Cat No: 80240

L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-[(aminoiminomethyl)thio]-L-norvaline, hydrobromide

Correlated keywords:

visualization assays colorimetric substrates L-arginases nitric oxides synthases NOS cells catalyzes oxidation citrulline N.omega.-hydroxy-L-arginine NOHA hydrolysis urea L-ornithine spectrophotometric measurements enzymes activity Km Kcat values thiols ellman's reagents DTNB 2-nitro-5-thiobenzoate 190374-70-0

Product Overview:
L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. Thioarginine (hydrobromide) is a colorimetric substrate for arginase that provides the basis for continuous spectrophotometric measurement of enzyme activity.{9082} It exhibits Km and kcat values of 0.5 mM and 18,000 min−1, respectively, which are similar to physiological substrate arginine.{9082} The thiol product of the reaction reacts with DTNB to produce 2-nitro-5-thiobenzoate for easy visualization at 405-420 nm.

Size	1 mg
Shipping	dry ice
Molecular Formula	C₆H₁₃N₃O₂S • HBr
SMILES	N/C(SCCC[C@H](N)C(O)=O)=N/[H].Br
Molecular Weight	272,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2921.29
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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