Mn(III)TMPyP

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Mn(III)TMPyP

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Cat No: 75852

Biochemicals - Ox Stress Reagents

Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst.{6039} SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin pentachloride

Correlated keywords:

SOD mimetic peroxynitrite superoxide dismutase

Product Overview:
Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst.{6039} SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to the dismutation of the superoxide radical (O2-). Mn(III)TMPyP is an SOD mimetic with increased stability to pH and hydrogen peroxide. The rate constant for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M−1s−1 and ~2 x 106 M−1s−1, respectively.{6039,4009} Mn(III)TMPyP protected and enhanced the growth of SOD null E. coli with a doubling time of 60 minutes (as compared to 240 minutes of the control) at 25 µM.{4009}

Size	10 mg
Shipping	dry ice
Molecular Formula	C₄₄H₃₆MnN₈ • 5Cl
SMILES	C[N+]1=CC=C(C=C1)C2=C(C=C3)[N]4=C3C(C5=CC=[N+](C)C=C5)=C6[N-]7[Mn+3]84[N-]9C2=CC=C9C(C(C=C%10)=CC=[N+]%10C)=C(C=C%11)[N]8=C%11C(C%12=CC=[N+](C)C=C%12)=C7C=C6.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]
Molecular Weight	909
Formulation	A black crystalline solid
Purity	≥95%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.