AM80 - C22H25NO3 - Bertin Bioreagent

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AM80

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Cat No: 71770

Biochemicals - Receptor Pharmacology

AM80 is a retinoic acid receptor agonist that is selective for RARα (Kd = 62 nM; AC50 = 1.46 nM) compared to RARβ (Kd = 280 nM; AC50 = 6.87 nM) and RARγ (Kd = 816 nM; AC50 = 148.7 nM).{24736} It demonstrates greater specific binding to RARα compared t...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]-benzoic acid

Correlated keywords:

synthetic retinoids retinobenzoic acids vitamin A retinoic RARs RAR? receptors agonists nuclear anticancer anti cancers anti-cancers acute promyelocytic leukemia APL antiproliferation differentiation ATRA-resistance AM-80 AMs 80 NSCs 608000 NSC-608000 NSC608000 selective ? .alpha. alpha a RARalpha RAR.alpha. RARa RAR? ? b beta .beta. RARb RARbeta RAR.beta. RARg RARgamma RAR.gamma. gamma .gamma. g RAR? ? binding binds antiproliferative effects cells inducing induces induction humans HL-60 HLs 60 differentiation suppress growth myeloid lymphoid malignant

Product Overview:
AM80 is a retinoic acid receptor agonist that is selective for RARα (Kd = 62 nM; AC50 = 1.46 nM) compared to RARβ (Kd = 280 nM; AC50 = 6.87 nM) and RARγ (Kd = 816 nM; AC50 = 148.7 nM).{24736} It demonstrates greater specific binding to RARα compared to retinoic acid (Item No. 11017), which exhibits little selectivity across RARα, β, or γ.{25644,24736} AM80 exhibits antiproliferative effects against acute promyelocytic leukemia cells, inducing human promyelocytic leukemia HL-60 cell differentiation with an ED50 value of 0.79 nM.{23266,25644} It has also been shown to suppress the growth of other myeloid and lymphoid malignant cells.{25644}

Size	5 mg
Shipping	dry ice
CAS Number	94497-51-5
Molecular Formula	C₂₂H₂₅NO₃
SMILES	CC(CCC1(C)C)(C)C2=C1C=C(NC(C3=CC=C(C(O)=O)C=C3)=O)C=C2
Molecular Weight	351,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.