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Diclofenac (sodium salt)

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    Diclofenac (sodium salt)
  • Diclofenac (sodium salt)
Cat No: 70680
Biochemicals - Small Molecule Inhibitors
Cayman

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively).{1791,1286} It is also an active metabolite of diclofenac methyl ester (Item No. 22218) and diclofe...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid, monosodium salt
Correlated keywords:
  • cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases synthase-1 synthase-2 inhibits
Product Overview:
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively).{1791,1286} It is also an active metabolite of diclofenac methyl ester (Item No. 22218) and diclofenac amide (Item No. 21969).{45201,52034} Diclofenac inhibits release of arachidonic acid (Item Nos. 90010
90010.1
10006607) induced by A23187 (Item No. 11016) in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 µM, respectively).{61276} Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats.{61277} Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Size 5 g
Shipping room temp.
CAS Number 15307-79-6
Molecular Formula C14H10Cl2NO2 • Na
SMILES ClC1=C(N([H])C2=C(CC([O-])=O)C=CC=C2)C(Cl)=CC=C1.[Na+]
Molecular Weight 318,1
Formulation A crystalline solid
Purity ≥99%
Custom Code 2916.31
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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