SC-58125

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SC-58125

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Cat No: 70655

Biochemicals - Small Molecule Inhibitors

SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib), DUP-697, and celecoxib. SC-58125 is a potent and time-dependent inhibitor of COX-2.{1299} When tested on the isolated recombinant enz...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole

Correlated keywords:

selective inhibitors inhibits COX-2 cox2 pghs2 pghs-2 prostaglandin synthases synthase-2 sc58125 cyclooxygenases diaryl heterocycles time-dependent

Product Overview:
SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib), DUP-697, and celecoxib. SC-58125 is a potent and time-dependent inhibitor of COX-2.{1299} When tested on the isolated recombinant enzymes, SC-58125 is at least 150 times more potent in the inhibition of COX-2 as COX-1.{3464} In cultured HUVEC cells, SC-58125 inhibits COX-2 with an IC50 of 70 nM.{5498} It also inhibits the growth of the COX-2 expressing cell line HCA-7 in nude mice at 5-10 mg/kg when given intraperitoneally.{6465}

Size	1 mg
Shipping	dry ice
CAS Number	162054-19-5
Molecular Formula	C₁₇H₁₂F₄N₂O₂S
SMILES	FC(C=C1)=CC=C1C2=CC(C(F)(F)F)=NN2C3=CC=C(S(=O)(C)=O)C=C3
Molecular Weight	384,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.