Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us

Baicalein

  • Zoom
    Baicalein
  • Baicalein
Cat No: 70610
Biochemicals - Lipids
Cayman

Baicalein is a flavonoid originally isolated from the roots of S. baicalensis that has diverse biological activities.{37567} It inhibits human platelet 12-lipoxygenase (12-LO) and human reticulocyte 15-LO-1 (IC50s = 0.64 and 1.6 µM, respectively) but ...

More

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Correlated keywords:
  • flavonoid scutellaria baicalensis georgi 12- LO inhibitors lipoxygenases lipids peroxidation apoptosis
Product Overview:
Baicalein is a flavonoid originally isolated from the roots of S. baicalensis that has diverse biological activities.{37567} It inhibits human platelet 12-lipoxygenase (12-LO) and human reticulocyte 15-LO-1 (IC50s = 0.64 and 1.6 µM, respectively) but is less potent at 15-LO-1 when the detergent Triton-X is present (IC50 = 38 µM).{37568} Baicalein inhibits lipid peroxidation, as assessed by production of thiobarbituric acid (TBARS; IC50 = 5 µM), and inhibits growth of Huh-7, KIM-1, and HLF human hepatocellular carcinoma cells (IC50s = 17-70 µg/ml).{5688,5627} Baicalein increases intracellular calcium levels by increasing release from the endoplasmic reticulum and via PKC-dependent calcium channels in the plasma membrane, leading to increases in reactive oxygen species (ROS), caspase-9 and -3 activation, and apoptosis in ZR-75-1 human breast cancer cells.{37569} Baicalein increases levels of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in BV-2 microglia and primary microglia and decreases the level of 12- and 15-LO products.{37570} It also decreases symptoms of experimental autoimmune encephalomyelitis (EAE) in a mouse model of multiple sclerosis, when administered at a dose of 75 mg/kg per day.
Size 50 mg
Shipping dry ice
CAS Number 491-67-8
Molecular Formula C15H10O5
SMILES OC1=CC2=C(C(C=C(C3=CC=CC=C3)O2)=O)C(O)=C1O
Molecular Weight 270,2
Formulation A crystalline solid
Purity ≥95%
Custom Code 2907.29
UNSPSC code 12352100

Click here to ask for your quote and get 15% off Cayman's products.

 

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : Baicalein There are 10 products.

Search