Indomethacin heptyl ester

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Cat No: 70271

Biochemicals - Small Molecule Inhibitors

Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans.{1286} Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivatized as an ester or amide. These derivatives ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, 1-heptyl ester

Correlated keywords:

esters derivatives COX-2 cox2 pghs2 pghs-2 prostaglandin synthases synthase-2 inhibitors inhibits selective selectivity cyclooxygenase

Product Overview:
Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans.{1286} Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivatized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC50 for indomethacin heptyl ester for the inhibition of human recombinant COX-2 is 0.04 µM, making it more than 1,700 times more potent as an inhibitor of COX-2 than COX-1.{8243} While indomethacin itself has an IC50 of 0.05 µM for the inhibition of COX-2, it also inhibits COX-1 with a corresponding IC50 of 0.67 µM.{8243}

Size	1 mg
Shipping	dry ice
CAS Number	282728-47-6
Molecular Formula	C₂₆H₃₀ClNO₄
SMILES	ClC1=CC=C(C(N2C(C=CC(OC)=C3)=C3C(CC(OCCCCCCC)=O)=C2C)=O)C=C1
Molecular Weight	456
Formulation	A solution in methyl acetate
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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