Farnesyl Pyrophosphate (ammonium

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Farnesyl Pyrophosphate (ammonium salt)

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Cat No: 63250

Biochemicals - Lipids

Farnesyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway and used in the biosynthesis of terpenes, terpenoids, and sterols.{8343} It also serves as a donor in post-translational isoprenylation of proteins.{24323} FPP has been identif...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

P-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl] ester-diphosphoric acid, triammonium salt

Correlated keywords:

372-97-4 748188-29-6 farnesyl disphaspate FDP FPP intermediates HMG-CoA HMGCoA HMG CoA reductase pathways sterol biosynthesis cholesterols isoprenylation P2Y12 receptors antagonist platelet aggregation PPAR? agonist nuclears ligands biosynthesis PPARs PPARg PPARgamma PPAR.gamma. PPAR-? PPAR-g PPAR-gamma PPAR-.gamma. ? g gamma .gamma. protein lipidation

Product Overview:
Farnesyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway and used in the biosynthesis of terpenes, terpenoids, and sterols.{8343} It also serves as a donor in post-translational isoprenylation of proteins.{24323} FPP has been identified as an antagonist of P2Y12 receptors (IC50 = 45 μM), attenuating platelet aggregation.{24324} It has also been shown to regulate adipocyte function as an endogenous PPARγ agonist.{24326} Additionally, because of a flexible hydrocarbon chain that enables different conformations, FPP is a promiscuous ligand for a subset of nuclear receptors.{24325}

Size	250 µg
Shipping	dry ice
CAS Number	116057-57-9
Molecular Formula	C₁₅H₂₅O₇P₂ • 3NH₄
SMILES	C/C(C)=C/CC/C(C)=C/CC/C(C)=C/COP(OP([O-])([O-])=O)([O-])=O.[NH4+].[NH4+].[NH4+]
Molecular Weight	433,4
Formulation	A solution in methanol:ammonium hydroxide (70:30)
Purity	≥95%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.