15(S)-HETE-biotin

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15(S)-HETE-biotin

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Cat No: 34722

15(S)-HETE is a major arachidonic acid metabolite produced by the 15-lipoxygenase pathway. It has been characterized as a potent inhibitor of 5-lipoxygenase.{6483,570} The mechanism by which 15(S)-HETE acts as a leukotriene inhibitor is not clear. In s...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraene-(2-biotinyl)hydrazide

Correlated keywords:

hydroxy fatty acids binding proteins receptors detection 15S-HETE-biotin 15(S)HETE-biotin 15S-HETES 15(S)-HETES 15(S)HETEs 15-HETEs 15HETEs

Product Overview:
15(S)-HETE is a major arachidonic acid metabolite produced by the 15-lipoxygenase pathway. It has been characterized as a potent inhibitor of 5-lipoxygenase.{6483,570} The mechanism by which 15(S)-HETE acts as a leukotriene inhibitor is not clear. In studies with P-18 mast/basophil cells, it was shown that specific 15-HETE receptors, rather than esterification, appeared to be involved in signal transduction.{1476} 15(S)-HETE-biotin can be used to detect 15(S)-HETE binding proteins and/or receptors.{6482}

Size	25 µg
Shipping	dry ice
Molecular Formula	C₃₀H₄₈N₄O₄S
SMILES	O=C(CCCCC1SCC(N2[H])C1N([H])C2=O)N([H])N([H])C(CCC/C=C\C/C=C\C/C=C\C=C\[C@@H](O)CCCCC)=O
Molecular Weight	560,8
Formulation	A solution in ethanol
Purity	≥95% (may contain trace amounts of free biotin)
Custom Code	2916.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.