Prion Protein (PrP) and namely its abnormal isoform, partially resistant to proteinase K (PrPres), is the only specific molecular marker of the Transmissible Spongiform Encephalopathies (TSEs) such as Bovine Spongiform Encephalopathie (BSE) or its huma...More
|Antigen||This anti-Prion Protein Monoclonal Antibody was raised against a preparation of SAF (scrapie associated fibrils) from infected hamster brain.|
Reconstitute the content of the vial in 1 mL of water.
For western blot analysis of PrPc, dilute the antibody to a final concentration of 1 µg/mL.
|Application Media||Reconstitute the content of the vial in 1 mL of water.|
|Formulation||lyophilized IgG with BSA|
Nishida N., et al. Successful Transmission of Three Mouse-Adapted Scrapie Strains to Murine Neuroblastoma Cell Lines Overrexpressing Wild-Type Mouse Prion Protein. Journal of Virology 320-325 (January 2000).
Vincent B., et al. Phorbol Ester-regulated Cleavage of Normal Prion Protein in HEK293 Human Cells and Murine Neurons. The journal of Biological Chemistry. Vol. 275, No 45, Issue of November 10, pp.35612-35616 (2000).
Demart S., et al. New Insight into Abnormal Prion Protein Using Monoclonal Antibodies.Biochemical and Biophysical Research Communications 265, 652-657 (1999).