4'-Demethylepipodophyllotoxin

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Cat No: 28393

Biochemicals - Microtubule Dynamics

4'-Demethylepipodophyllotoxin is an inhibitor of tubulin polymerization (IC50 = 13 μM).{48556} It inhibits the growth of human HepG2 liver, HeLa cervical, A549 lung, and BGC-823 stomach cancer cells in vitro (IC50s = 18.74, 15.96, 52.08, and 21.26 μM,...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(5R,5aR,8aR,9S)-5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3?,4?:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

Correlated keywords:

104183-79-1 142561-77-1 Demethyl epipodo phyllotoxin Hep G2 A 549 BGC823 noncancerous HL7702 DMEP

Product Overview:
4'-Demethylepipodophyllotoxin is an inhibitor of tubulin polymerization (IC50 = 13 μM).{48556} It inhibits the growth of human HepG2 liver, HeLa cervical, A549 lung, and BGC-823 stomach cancer cells in vitro (IC50s = 18.74, 15.96, 52.08, and 21.26 μM, respectively).{48557} 4'-Demethylepipodophyllotoxin also inhibits the growth of non-cancerous human HL-7702 liver cells (IC50 = 13.04 μM).

Size	1 g
Shipping	dry ice
CAS Number	6559-91-7
Molecular Formula	C₂₁H₂₀O₈
SMILES	O=C(OC1)[C@]([C@@]1([H])[C@@H]2O)([H])[C@@](C3=CC(OC)=C(O)C(OC)=C3)([H])C4=C2C=C(OCO5)C5=C4
Molecular Weight	400,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.20
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.