Xylometazoline (hydrochloride)

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Cat No: 27797

Biochemicals - Receptor Pharmacology

Xylometazoline is an α-adrenergic receptor (α-AR) agonist that binds to α1A-, α1B-, α1D-, α2A-, α2B-, and α2C-ARs in a radioligand binding assay (IC50s = 0.08, 0.56, 0.45, 0.98, 1.8, and 0.22 μM, respectively).{51089} It increases intracellular calciu...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1H-imidazole, monohydrochloride

Correlated keywords:

526-36-3 8057-34-9 28096-10-8 Galazolin Neo-Rinoleina Novorin Olynth Otrivin Otrivine Oxymetalozine Rhinex Rhinostop Therapin Xymelin Brizolin Synephrine II ?AR HEK 293 5HT 5HT1 5HT1D 5HT1B Pro5

Product Overview:
Xylometazoline is an α-adrenergic receptor (α-AR) agonist that binds to α1A-, α1B-, α1D-, α2A-, α2B-, and α2C-ARs in a radioligand binding assay (IC50s = 0.08, 0.56, 0.45, 0.98, 1.8, and 0.22 μM, respectively).{51089} It increases intracellular calcium levels in HEK293 cells transfected with human α2B-ARs (EC50 = 99 μM) but not other α-ARs. Xylometazoline is also an agonist of the serotonin (5-HT) receptor subtype 5-HT1 (Kis = 0.7 and 14 nM for the human 5-HT1D and 5-HT1B receptors, respectively).{51090} It inhibits forskolin-induced cAMP production in CHO Pro 5 cells expressing human 5-HT1D and 5-HT1B receptors by 62 and 49%, respectively, when used at a concentration of 1 μM. Xylometazoline (0.25 μg/ml) induces contraction of isolated dog nasal mucosal blood vessels and reduces nasal patency in dogs when administered topically or intravenously.{51091}

Size	1 g
Shipping	dry ice
CAS Number	1218-35-5
Molecular Formula	C₁₆H₂₄N₂ • HCl
SMILES	CC1=C(CC2=NCCN2)C(C)=CC(C(C)(C)C)=C1.Cl
Molecular Weight	280,8
Formulation	A solid
Purity	≥98%
Custom Code	2933.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.