Pinosylvin

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Pinosylvin

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Cat No: 27612

Biochemicals - Lipids

Pinosylvin is a stilbene originally isolated from pine heartwood that has diverse biological activities.{51006,51007,51008,51009,51010,51011} It activates sirtuin 1 (SIRT1) and induces glucose uptake in isolated rat L6 skeletal muscle myotubes.{51007}...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-[(1E)-2-phenylethenyl]-1,3-benzenediol

Correlated keywords:

SIRT-1 MMP2 MMP9 Ammp HT1080 CT-26 Leucoagaricus anti-feedant 3,5-Dihydroxytrans L 6 1MMP Lepus Pinosylvine

Product Overview:
Pinosylvin is a stilbene originally isolated from pine heartwood that has diverse biological activities.{51006,51007,51008,51009,51010,51011} It activates sirtuin 1 (SIRT1) and induces glucose uptake in isolated rat L6 skeletal muscle myotubes.{51007} Pinosylvin reduces radial growth in a panel of 28 plant pathogenic fungi when used at a concentration of 100 μg/ml.{51008} It reduces expression of matrix metalloproteinase-2 (MMP-2), MMP-9, and membrane type 1-MMP in and inhibits migration of HT-1080 cells.{51009} Pinosylvin (10 mg/kg, i.p.) reduces the number of tumor nodules and lung tumor weight in a CT26 mouse xenograft model of metastatic colon cancer. It decreases hind paw volume and myeloperoxidase (MPO) activity in a rat model of adjuvant-induced arthritis.{51010} Pinosylvin also exhibits plant antifeedant activity against L. americanus (snowshoe hares).{51011}

Size	1 mg
Shipping	dry ice
CAS Number	22139-77-1
Molecular Formula	C₁₄H₁₂O₂
SMILES	OC1=CC(/C=C/C2=CC=CC=C2)=CC(O)=C1
Molecular Weight	212,2
Formulation	A solid
Purity	≥98%
Custom Code	2918.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.