Triflupromazine (hydrochloride)

Biochemicals - Receptor Pharmacology

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Cat No: 27610

Biochemicals - Receptor Pharmacology

Triflupromazine is a phenothiazine with diverse biological activities.{47511,47512,47513,47514} It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay).{47511} Triflupromazine inhibits serotonin ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N,N-dimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine, monohydrochloride

Correlated keywords:

146-54-3 MC 4703 MC4703 Adazine Flumazin Neocalm Neoprin Nivoman Syquil Vespral Vesprin Vetame Tri-flu-promazine 5HT Trypanosoma Staphylococcus MIC Salmonella anti-psychotic Fluorofen

Product Overview:
Triflupromazine is a phenothiazine with diverse biological activities.{47511,47512,47513,47514} It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay).{47511} Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM).{47512} It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM.{47513} Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal.{47514} Formulations containing triflupromazine were previously used as antipsychotics.

Size	1 g
Shipping	dry ice
CAS Number	1098-60-8
Molecular Formula	C₁₈H₁₉F₃N₂S • HCl
SMILES	FC(F)(F)C1=CC=C2SC3=CC=CC=C3N(CCCN(C)C)C2=C1.Cl
Molecular Weight	388,9
Formulation	A solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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