Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

Cisplatin

  • Zoom
    Cisplatin
  • Cisplatin
Cat No: 13119
Biochemicals - Anti-Infection
Cayman
€38.00
Price is excluding VAT and does not include packaging neither shipping

Cisplatin is a platinum-containing compound that acts as a DNA-crosslinking agent and interferes with replication and transcription, culminating in apoptosis.{25182} It forms intra- and interstrand crosslinks with DNA with intrastrand guanine-to-guani...

More

This product can only be bought through Cayman Chemical. Please contact us.

- +
Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • (SP-4-2)-diamminedichloro-platinum
Correlated keywords:
  • 96081-74-2 936542-99-3 cancers apoptosis infectious diseases DNA damages platinum-containing platinum containing alkylating agents therapy therapies treatments RecA recombinases Mycobacterium tuberculosis blocking blocks blockages proteins splicing cells growths repairs chemotherapy chemo abiplatin biocisplatinum briplatin CACP CDDP CP ethypharm CPDC CPDD CPPD cismaplat cisplatino cisplatinum cisplatyl citoplatino DDP antitumor anti-tumor anti tumors fauldiscopla IA-call IA calls lederplatin liplacis lipoplatin NSCs 119875 NSC119875 NSC-119875 neoplatin platamine platiblastin platidiam platinex platinol AQ platinoxan platistin platosin rand randa SPIs 077 SPI077 SPI-077 SPI077B103 077B103 TRs 170 TR170 TR-170 cis-DDP cis-diaminedichloroplatinum cis-diaminodichloroplatinum cis-diamminedichloroplatinum cis-platin cis-platine cos-platinous cis-platinum testicular ovarian cervical bladders lungs inhibits inhibitions inhibitors cis-diamminedichloroplatinum(II) dichloride
Product Overview:
Cisplatin is a platinum-containing compound that acts as a DNA-crosslinking agent and interferes with replication and transcription, culminating in apoptosis.{25182} It forms intra- and interstrand crosslinks with DNA with intrastrand guanine-to-guanine or guanine-to-alanine links accounting for the majority of DNA binding.{39782} Cisplatin halts the cell cycle at the G2/M phase in vitro and is active against murine tumors transplanted into mice and in mouse xenograft models, including a reduction in tumor growth in a model of squamous cell carcinoma of the head and neck when administered at doses ranging from 7.5 to 12.5 mg/kg.{39783,39784} Cisplatin also inhibits the RecA recombinase of M. tuberculosis (IC50 = 2 µM), blocking protein splicing and cell growth.{26034} Formulations containing cisplatin have been used, alone and in combination therapy, in the treatment of a variety of cancers.
Size 50 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 15663-27-1
Molecular Formula Cl2H6N2Pt
SMILES [Cl-][Pt+2]([NH3])([NH3])[Cl-]
Molecular Weight 300,1
Formulation A crystalline solid
Purity ≥95%
Custom Code 2801.10
UNSPSC code 12352300

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : Cisplatin There are 10 products.

Search