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  • Cisplatin
Cat No: 13119
Biochemicals - Anti-Infection

Cisplatin is a platinum-containing compound that acts as a DNA-crosslinking agent and interferes with replication and transcription, culminating in apoptosis.{25182} It forms intra- and interstrand crosslinks with DNA with intrastrand guanine-to-guani...


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Territorial Availability: Available through Bertin Technologies only in France
  • (SP-4-2)-diamminedichloro-platinum
Correlated keywords:
  • 96081-74-2 936542-99-3 cancers apoptosis infectious diseases DNA damages platinum-containing platinum containing alkylating agents therapy therapies treatments RecA recombinases Mycobacterium tuberculosis blocking blocks blockages proteins splicing cells growths repairs chemotherapy chemo abiplatin biocisplatinum briplatin CACP CDDP CP ethypharm CPDC CPDD CPPD cismaplat cisplatino cisplatinum cisplatyl citoplatino DDP antitumor anti-tumor anti tumors fauldiscopla IA-call IA calls lederplatin liplacis lipoplatin NSCs 119875 NSC119875 NSC-119875 neoplatin platamine platiblastin platidiam platinex platinol AQ platinoxan platistin platosin rand randa SPIs 077 SPI077 SPI-077 SPI077B103 077B103 TRs 170 TR170 TR-170 cis-DDP cis-diaminedichloroplatinum cis-diaminodichloroplatinum cis-diamminedichloroplatinum cis-platin cis-platine cos-platinous cis-platinum testicular ovarian cervical bladders lungs inhibits inhibitions inhibitors cis-diamminedichloroplatinum(II) dichloride
Product Overview:
Cisplatin is a platinum-containing compound that acts as a DNA-crosslinking agent and interferes with replication and transcription, culminating in apoptosis.{25182} It forms intra- and interstrand crosslinks with DNA with intrastrand guanine-to-guanine or guanine-to-alanine links accounting for the majority of DNA binding.{39782} Cisplatin halts the cell cycle at the G2/M phase in vitro and is active against murine tumors transplanted into mice and in mouse xenograft models, including a reduction in tumor growth in a model of squamous cell carcinoma of the head and neck when administered at doses ranging from 7.5 to 12.5 mg/kg.{39783,39784} Cisplatin also inhibits the RecA recombinase of M. tuberculosis (IC50 = 2 µM), blocking protein splicing and cell growth.{26034} Formulations containing cisplatin have been used, alone and in combination therapy, in the treatment of a variety of cancers.
Size 50 mg
Shipping dry ice
CAS Number 15663-27-1
Molecular Formula Cl2H6N2Pt
SMILES [Cl-][Pt+2]([NH3])([NH3])[Cl-]
Molecular Weight 300,1
Formulation A crystalline solid
Purity ≥95%
Custom Code 2801.10
UNSPSC code 12352300

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