CP 31,398 (hydrochloride)

Confirm delete?

Zoom

Cat No: 27455

Biochemicals - More Biochemicals

CP 31,398 is a p53 stabilizing agent.{42846} It increases active mutant p53 and p53 reporter gene expression without increasing total protein levels of p53 in H1299 lung cancer cells transfected with mutant p53. CP 31,398 is cytotoxic to a panel of 12...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N3-[2-[2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine, dihydrochloride

Correlated keywords:

259199-65-0 CP-31398 CP31398 p-53 H-1299 A375S2 DLD1 WT

Product Overview:
CP 31,398 is a p53 stabilizing agent.{42846} It increases active mutant p53 and p53 reporter gene expression without increasing total protein levels of p53 in H1299 lung cancer cells transfected with mutant p53. CP 31,398 is cytotoxic to a panel of 12 human glioma cell lines expressing wild-type or mutant p53 (EC50s = 11.2-22.2 μM).{42847} In vivo, CP 31,398 (100 mg/kg) decreases tumor growth by 50% in an A375.S2 melanoma mouse xenograft model and completely inhibits tumor growth in a DLD-1 colon cancer mouse xenograft model.{42846} Dietary administration of CP 31,398 (50 and 100 ppm) suppresses lung adenocarcinoma formation in a mouse model of tobacco carcinogen-induced lung adenoma and adenocarcinoma formation.{42848}

Size	1 mg
Shipping	dry ice
CAS Number	1217195-61-3
Molecular Formula	C₂₂H₂₆N₄O • 2HCl
SMILES	CN(C)CCCNC1=NC(/C=C/C2=CC=C(OC)C=C2)=NC3=C1C=CC=C3.Cl.Cl
Molecular Weight	435,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2921.29
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.