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16,16-dimethyl Prostaglandin E2

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    16,16-<wbr/>dimethyl Prostaglandin E<sub>2</sub>
  • 16,16-<wbr/>dimethyl Prostaglandin E<sub>2</sub>
Cat No: 14750
Biochemicals - Lipids
Cayman
€91.00
Price is excluding VAT and does not include packaging neither shipping

16,16-dimethyl PGE2 is a competitive inhibitor of 15-hydroxy PGDH, but it is not a substrate for the enzyme.{1789} Because of its resistance to metabolism by 15-hydroxy PGDH, it has a prolonged half-life in vivo. 16,16-dimethyl PGE2 acts as an agonist...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 9-oxo-11α,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid
Correlated keywords:
  • 16,16-dimethyl-PGE2 cytoprotection prostaglandins inhibitor inhibits dmpge2 dm-pge2 dmprostaglandin dm-prostaglandin biochemical prostaglandins EP receptor agonist stem cell research reproductive biology inflammation 15-hydroxy PGDH hematopoietic
Product Overview:
16,16-dimethyl PGE2 is a competitive inhibitor of 15-hydroxy PGDH, but it is not a substrate for the enzyme.{1789} Because of its resistance to metabolism by 15-hydroxy PGDH, it has a prolonged half-life in vivo. 16,16-dimethyl PGE2 acts as an agonist on most EP receptor subtypes, and has been used experimentally to induce cervical ripening, uterine contraction, and prevent ulceration of the gastric mucosa in rats and dogs.{437,1422} The Kd for activation of isolated EP2 receptors is about 1 nM.{1422} 16,16-dimethyl PGE2 can be used to preserve the self-renewal properties while preventing the differentiation of hematopoietic stem cells during expansion in culture.{27133,27095}
Size 1 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 39746-25-3
Molecular Formula C22H36O5
SMILES O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C(C)(C)CCCC)[C@H](O)C1
Molecular Weight 380,5
Formulation A solution in methyl acetate
Purity ≥98%
Custom Code 2937.50
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

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Cross selling for this product : 16,16-<wbr/>dimethyl Prostaglandin E<sub>2</sub> There are 3 products.

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