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16,16-dimethyl Prostaglandin E2

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    16,16-<wbr/>dimethyl Prostaglandin E<sub>2</sub>
  • 16,16-<wbr/>dimethyl Prostaglandin E<sub>2</sub>
Cat No: 14750
Biochemicals - Lipids
Cayman

16,16-dimethyl PGE2 is a competitive inhibitor of 15-hydroxy PGDH, but it is not a substrate for the enzyme.{1789} Because of its resistance to metabolism by 15-hydroxy PGDH, it has a prolonged half-life in vivo. 16,16-dimethyl PGE2 acts as an agonist...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 9-oxo-11?,15R-dihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid
Correlated keywords:
  • 16,16-dimethyl-PGE2 cytoprotection prostaglandins inhibitor inhibits dmpge2 dm-pge2 dmprostaglandin dm-prostaglandin biochemical prostaglandins EP receptor agonist stem cell research reproductive biology inflammation 15-hydroxy PGDH hematopoietic
Product Overview:
16,16-dimethyl PGE2 is a competitive inhibitor of 15-hydroxy PGDH, but it is not a substrate for the enzyme.{1789} Because of its resistance to metabolism by 15-hydroxy PGDH, it has a prolonged half-life in vivo. 16,16-dimethyl PGE2 acts as an agonist on most EP receptor subtypes, and has been used experimentally to induce cervical ripening, uterine contraction, and prevent ulceration of the gastric mucosa in rats and dogs.{437,1422} The Kd for activation of isolated EP2 receptors is about 1 nM.{1422} 16,16-dimethyl PGE2 can be used to preserve the self-renewal properties while preventing the differentiation of hematopoietic stem cells during expansion in culture.{27133,27095}
Size 1 mg
Shipping dry ice
CAS Number 39746-25-3
Molecular Formula C22H36O5
SMILES O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C(C)(C)CCCC)[C@H](O)C1
Molecular Weight 380,5
Formulation A solution in methyl acetate
Purity ≥95%
Custom Code 2937.50
UNSPSC code 12352100

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