ACTH (1-17) (human, mouse, rat,

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ACTH (1-17) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

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Cat No: 27429

Biochemicals - Peptides

ACTH (1-17) is a peptide fragment of adrenocorticotropic hormone (ACTH; Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response.{45140} It binds to melanocortin receptors (MCRs; Kis = 0.23, 14, 419, and...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

?1-17-corticotropin, trifluoroacetate salt

Correlated keywords:

7266-47-9 MC 1R 3R 4R 5R HEK 293 SYSMEHFRWGKPVGKKROH

Product Overview:
ACTH (1-17) is a peptide fragment of adrenocorticotropic hormone (ACTH; Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response.{45140} It binds to melanocortin receptors (MCRs; Kis = 0.23, 14, 419, and 4,240 nM for MC1R, MC3R, MC4R, and MC5R, respectively).{48427} It is an agonist at MC1R, increasing adenylate cyclase activity with an EC50 value of 3.02 nM in HEK293 cells expressing MC1R.{49034} ACTH (1-17) (160 µg/kg, i.v.) increases mean arterial blood pressure (MAP) following bleeding-induced hypotension in a rat model of hemorrhagic shock 15-30 minutes after administration.{48428} It induces melanogenesis in a biphasic manner (EC50s = 0.0001 and 0.08 nM) and differentiation of melanocytes when used at concentrations ranging from 0.01 to 1,000 nM.{49034,48426}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₉₅H₁₄₅N₂₉O₂₃S • XCF₃COOH
SMILES	[H]N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CN
Molecular Weight	2093,4
Formulation	A solid
Purity	≥98%
Custom Code	3504.00
UNSPSC code	12352100

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ISO Guide 34:2009

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