GHK - C14H24N6O4 - Bertin Bioreagent

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GHK

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Cat No: 27168

Biochemicals - Peptides

GHK is a peptide released during extracellular matrix (ECM) protein degradation following tissue injury.{48385} It binds to copper to form GHK-Cu, a complex with diverse biological activities, including roles in tissue remodeling and wound healing, ha...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

glycyl-L-histidyl-L-lysine

Correlated keywords:

98039-93-1 GHKCu p 63 ? 6 ? 1 TNF? IL6 tumor necrosis factor interleukin NSC379527 tripeptide Growth-modulating Kollaren Liver cell growth factor GlyHisLys

Product Overview:
GHK is a peptide released during extracellular matrix (ECM) protein degradation following tissue injury.{48385} It binds to copper to form GHK-Cu, a complex with diverse biological activities, including roles in tissue remodeling and wound healing, hair growth, and suppression of inflammation. GHK (1 µM) increases keratinocyte proliferation in vitro, as well as the number of cells positive for the keratinocyte stem cell marker p63 and the protein levels of integrin α6 and β1 in a skin equivalent model.{48386} It also reduces infiltration of inflammatory cells and decreases TNF-α and IL-6 protein levels in bronchoalveolar lavage fluid (BALF) in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).{48387}

Size	1 mg
Shipping	dry ice
CAS Number	49557-75-7
Molecular Formula	C₁₄H₂₄N₆O₄
SMILES	O=C(N[C@H](C(O)=O)CCCCN)[C@@H](NC(CN)=O)CC1=CN=CN1
Molecular Weight	340,4
Formulation	A solid
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.