Etelcalcetide (hydrochloride)

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Cat No: 26901

Biochemicals - Receptor Pharmacology

Etelcalcetide is a peptide agonist of the calcium-sensing receptor (CaSR).{47345} It is selective for CaSR over a panel of 33 receptors and ion channels, as well as the norepinephrine transporter at 10 µM. Etelcalcetide increases intracellular calcium...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide, disulfide with L-cysteine, hydrochloride

Correlated keywords:

1262780-97-1 AMG416 AMG 416 KAI4169 Ca SR HEK 293T hyper-thyroidism highphosphorus

Product Overview:
Etelcalcetide is a peptide agonist of the calcium-sensing receptor (CaSR).{47345} It is selective for CaSR over a panel of 33 receptors and ion channels, as well as the norepinephrine transporter at 10 µM. Etelcalcetide increases intracellular calcium levels in HEK293T cells expressing the human CaSR receptor with an EC50 value of 0.53 µM. It also inhibits parathyroid secretion from primary rat parathyroid cells (EC50 = 0.36 µM in the presence of calcium). Etelcalcetide (0.3, 1, and 3 mg/kg) decreases parathyroid hormone and calcium levels in plasma and serum, respectively, in a model of chronic renal insufficiency with secondary hyperthyroidism in nephrectomized rats fed a high-phosphorus diet. Formulations containing etelcalcetide have been used in the treatment of secondary hyperparathyroidism in adult patients with chronic kidney disease undergoing hemodialysis.

Size	1 mg
Shipping	dry ice
CAS Number	1334237-71-6
Molecular Formula	C₃₈H₇₃N₂₁O₁₀S₂ • XHCl
SMILES	O=C([C@H](NC([C@H](NC([C@H](NC([C@@H](CSSC[C@@H](C(O)=O)N)NC(C)=O)=O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)N[C@@H](C(N[C@@H](C(N[C@H](CCCNC(N)=N)C(N)=O)=O)C)=O)CCCNC(N)=N.Cl
Molecular Weight	1048,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.