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Cetirizine-d8 (hydrochloride)

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    Cetirizine-d<sub>8</sub> (hydro<wbr/>chloride)
  • Cetirizine-d<sub>8</sub> (hydro<wbr/>chloride)
Cat No: 26445
Biochemicals - Isotopically Labeled Standards
Cayman

Cetirizine-d8 (hydrochloride) is intended for use as an internal standard for the quantification of cetirizine (Item No. 19686), (R)-cetirizine (Item No. 23992), and (S)-cetirizine by GC- or LC-MS. Cetirizine is a bioactive carboxylated metabolite of ...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl-d8]ethoxy]-acetic acid, dihydrochloride
Correlated keywords:
  • 774596-22-4 UCB-P 071 UCBP 071 UCB-P071 UCBP071 GCMS LCMS deuterated deuterium H-1 anti-histamine B-4
Product Overview:
Cetirizine-d8 (hydrochloride) is intended for use as an internal standard for the quantification of cetirizine (Item No. 19686), (R)-cetirizine (Item No. 23992), and (S)-cetirizine by GC- or LC-MS. Cetirizine is a bioactive carboxylated metabolite of hydroxyzine (Item No. 24039) that acts as a selective histamine H1 receptor antagonist (Ki = 10 nM).{15199,31604} As a second generation antihistamine, it is non-sedating due to low lipophilicity, which prevents blood-brain barrier transit.{31603} Cetirizine is a racemic mixture composed of equal amounts of two enantiomers, (R)-cetirizine (Item No. 23992) and (S)-cetirizine, with pharmacological activity residing primarily in the (R) isomer.{31604} Cetirizine inhibits eosinophil chemotaxis and leukotriene B4 (LTB4; Item No. 20110) release independent from H1 antagonism.{31605} It inhibits aerosol histamine-induced bronchospasm in guinea pigs (ED50 = 100 μg/kg, p.o.).{47108} Formulations containing cetirizine have been used in the treatment of allergic rhinitis and chronic urticaria.
Size 500 µg
Shipping dry ice
CAS Number 2070015-04-0
Molecular Formula C21H17ClD8N2O3 • 2HCl
SMILES ClC1=CC=C(C(N2C([2H])([2H])C([2H])([2H])N(CCOCC(O)=O)C([2H])([2H])C2([2H])[2H])C3=CC=CC=C3)C=C1.Cl.Cl
Molecular Weight 469,9
Formulation A solid
Purity ≥99% deuterated forms (d1-d8)
Custom Code 3822.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

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