Tegafur

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Tegafur

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Cat No: 26076

Biochemicals - Small Molecule Inhibitors

Tegafur is an orally bioavailable prodrug form of 5-fluorouracil (5-FU; Item No. 14416).{46033} It is converted to 5-FU in vivo enzymatically or by cytochrome P450 oxidation. Tegafur inhibits proliferation of HT-29, BxPC-3, and Panc02 cells (IC50s = 2...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione

Correlated keywords:

35959-67-2 37308-51-3 56767-38-5 65732-47-0 73120-84-0 79107-97-4 Citofur Coparogin Exonal FT 207 FT207 Fental Fluaid Fluorafur Fluorofur Franrose Ftorafur Fulaid Fulfeel Furafluor Furofutran Futraful Lamar Lifril MJF 12264 MJF12264 Riol Sinoflurol Sunfural TS1 Tefsiel C Utefos 5FU HT29 BxPC3 Panc-02 HT27 41ST NSC148958 Neberk Nitobanil CYP450

Product Overview:
Tegafur is an orally bioavailable prodrug form of 5-fluorouracil (5-FU; Item No. 14416).{46033} It is converted to 5-FU in vivo enzymatically or by cytochrome P450 oxidation. Tegafur inhibits proliferation of HT-29, BxPC-3, and Panc02 cells (IC50s = 201, 172, and 179 µM, respectively).{46034} It also reduces tumor growth in an HT-27 colon carcinoma mouse xenograft model when administered at a dose of 50 mg/kg and in a 4-1ST gastric carcinoma mouse xenograft model when used in combination with uracil.{46034,46035} Formulations containing tegafur, in combination with uracil, have been used in the treatment of cancer.

Size	250 mg
Shipping	dry ice
CAS Number	17902-23-7
Molecular Formula	C₈H₉FN₂O₃
SMILES	O=C1N(C2OCCC2)C=C(F)C(N1)=O
Molecular Weight	200,2
Formulation	A solid
Purity	≥98%
Custom Code	2932.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.