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Penfluridol

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    Penfluridol
  • Penfluridol
Cat No: 26071
Biochemicals - Receptor Pharmacology
Cayman

Penfluridol is a first generation typical antipsychotic that binds to dopamine receptors (IC50 = 5.6 nM).{42533} It binds to dopamine D4 receptors and also to serotonin (5-HT) receptors (Kis = 31 and 63.1 nM, respectively).{42534,42535} Penfluridol (1...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol
Correlated keywords:
  • R16341 McN-JR-16341 McNJR JR16341 McNJR16341 Semap anti-psychotic 5HT ?-6 ?-4 4T-1 4-T1
Product Overview:
Penfluridol is a first generation typical antipsychotic that binds to dopamine receptors (IC50 = 5.6 nM).{42533} It binds to dopamine D4 receptors and also to serotonin (5-HT) receptors (Kis = 31 and 63.1 nM, respectively).{42534,42535} Penfluridol (1.25 and 2.5 mg/kg) inhibits stereotypic behavior induced by apomorphine (Item No. 16094) in cynomolgus monkeys.{42536} It also inhibits proliferation of triple-negative breast cancer cells (TNBCs; IC50s = 6-8 µM), as well as inhibits migration and invasion of TNBCs and decreases the expression of integrin α6 and β4.{42537} Penfluridol reduces tumor growth and metastasis in a 4T1 orthotopic mouse model when administered at a dose of 10 mg/kg per day.
Size 100 mg
Shipping dry ice
CAS Number 26864-56-2
Molecular Formula C28H27ClF5NO
SMILES FC1=CC=C(C(CCCN2CCC(C3=CC=C(Cl)C(C(F)(F)F)=C3)(O)CC2)C4=CC=C(F)C=C4)C=C1
Molecular Weight 524
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.39
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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