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NAADP (sodium salt)

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    NAADP (sodium salt)
  • NAADP (sodium salt)
Cat No: 25992
Biochemicals - Ion Channel Modulation
Cayman

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization.{47014,29682} It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then stimulates large-...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 2?-(dihydrogen phosphate), adenosine 5?-(trihydrogen diphosphate), P??5?-ester with 3-carboxy-1-?-D-ribofuranosylpyridinium, inner salt, tetrasodium salt
Correlated keywords:
  • 5502-96-5 196083-48-4 1095047-58-7 TPC 2 1 VEGF RyR 3 nicotine-TPN
Product Overview:
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization.{47014,29682} It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then stimulates large-scale calcium release from granules and the endoplasmic reticulum mediated by type 1 ryanodine receptors (RyR2s), RyR3s, and inositol-(1,4,5)-triphosphate receptors (IP3Rs).{47014,47012} NAADP induces calcium mobilization in sea urchin and starfish eggs post fertilization to block polyspermy and activate embryogenesis.{47012} NAADP-induced calcium mobilization induces VEGF-mediated angiogenesis in human umbilical vein endothelial cells (HUVECs). It also alkalizes lysosomal pH thereby inhibiting fusion between autophagosomes and lysosomes and arresting autophagic flux in mouse embryonic stem cells.{47013}
Size 1 mg
Shipping dry ice
Molecular Formula C21H23N6O18P3 • 4Na
SMILES NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC(C([O-])=O)=CC=C5)O4)([O-])=O)([O-])=O)O3.[Na+].[Na+].[Na+].[Na+]
Molecular Weight 832,3
Formulation A solid
Purity ≥95%
Custom Code 2933.39
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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