Lipid A Monophosphoryl from Salmonella minnesota R595

Biochemicals - Lipids

Cat No: 25848

Biochemicals - Lipids

Lipid A monophosphoryl from Salmonella minnesota R595 is a non-toxic fragment of lipopolysaccharide (LPS) extracted from wild-type S. minnesota R595 and a TRIF biased toll-like receptor 4 (TLR4) agonist.{39965} Lipid A monophosphoryl induces T cell cl...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

497156-01-1 R-595 WT nontoxic TLR-4 GCSF IL10 IP10 MCP1 MyD-88 IL1? IL6 MIP1? MPLA-SM MPLASM IFN?

Product Overview:
Lipid A monophosphoryl from Salmonella minnesota R595 is a non-toxic fragment of lipopolysaccharide (LPS) extracted from wild-type S. minnesota R595 and a TRIF biased toll-like receptor 4 (TLR4) agonist.{39965} Lipid A monophosphoryl induces T cell clonal expansion and TRIF-dependent production of G-CSF, IL-10, IP-10, and MCP-1 but has no effect on MyD88-dependent production of the inflammatory cytokines IL-1β, IL-6, MIP-1α, and IFN-γ in mice, indicating decreased potential for inflammatory toxicity compared to LPS and use as a non-toxic vaccine adjuvant.

Size	1 mg
Shipping	wet ice
Formulation	A lyophilized powder
Custom Code	2915.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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