Menaquinone 4-d7

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Menaquinone 4-d₇

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Cat No: 25709

Biochemicals - Isotopically Labeled Standards

Menaquinone 4-d7 (MK-4-d7) is intended for use as an internal standard for the quantification of MK-4 (Item No. 18423) by GC- or LC-MS. MK-4 is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(methyl-d3)-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-naphthalenedione-5,6,7,8-d4

Correlated keywords:

MK4 deuterated deuterium Hep-G2 3B Huh-7 NF?B

Product Overview:
Menaquinone 4-d7 (MK-4-d7) is intended for use as an internal standard for the quantification of MK-4 (Item No. 18423) by GC- or LC-MS. MK-4 is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units in the side chain.{29936} It is formed primarily via conversion of vitamin K1 (Item No. 21051) in vivo and accumulates in various tissues, including the brain.{37777,37778} MK-4 halts the cell cycle at the G1 phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner.{37779} It also inhibits IκB kinase (IKK) activity, IκBα phosphorylation, and the transcriptional activity of NF-κB. Vitamin K2 may have a role in bone metabolism.{29936}

Size	250 µg
Shipping	dry ice
CAS Number	1233937-25-1
Molecular Formula	C₃₁H₃₃D₇O₂
SMILES	[2H]C1=C2C(C(C(C([2H])([2H])[2H])=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)C2=O)=O)=C([2H])C([2H])=C1[2H]
Molecular Weight	451,7
Formulation	An oil
Purity	≥99% deuterated forms (d1-d7)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.