Oridonin

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Oridonin

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Cat No: 25665

Biochemicals - Kinase Inhibitors

Oridonin is a diterpenoid that has been found in R. rubescens and has anti-inflammatory and anticancer properties.{42522,42523} It is an inhibitor of AKT1 and AKT2 (IC50s = 8.4 and 8.9 µM, respectively).{42522} Oridonin inhibits proliferation of KYSE7...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7,20-epoxy-1?,6?,7?,14R-tetrahydroxy-kaur-16-en-15-one

Correlated keywords:

18288-82-9 Oridonine Isodonol NSC250682 antiinflammatory anti-cancer Rhodamnia AKT-1 2 KYSE-70 410 450 NLRP-3 WT

Product Overview:
Oridonin is a diterpenoid that has been found in R. rubescens and has anti-inflammatory and anticancer properties.{42522,42523} It is an inhibitor of AKT1 and AKT2 (IC50s = 8.4 and 8.9 µM, respectively).{42522} Oridonin inhibits proliferation of KYSE70, KYSE410, and KYSE450 esophageal cancer cells in a dose-dependent manner, halts the cell cycle at the G2/M phase, and induces apoptosis when used at a concentration of 20 µM. It decreases the expression of cleaved poly(ADP-ribose) polymerase (PARP), caspase-3, caspase-7, and Bims and the protein levels of phosphorylated AKT and reduces AKT activity. Oridonin reduces tumor growth in patient-derived mouse tumor models when administered at doses of 40 and 160 mg/kg. Oridonin is also an inhibitor of NLRP3 inflammasome assembly and activation.{42523} It inhibits inflammation in wild-type, but not Nlrp3-/-, mice in a model of high-fat diet-induced type 2 diabetes when administered at a dose of 3 mg/kg.

Size	5 mg
Shipping	dry ice
CAS Number	28957-04-2
Molecular Formula	C₂₀H₂₈O₆
SMILES	O=C1[C@@]2([C@]3([H])O)[C@@]4(O)[C@@H](O)[C@]5([H])C(C)(C)CC[C@H](O)[C@@]5(CO4)[C@]2([H])CC[C@@]3([H])C1=C
Molecular Weight	364,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2902.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.