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5,7-Dichlorokynurenic Acid

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    5,7-Dichloro<wbr/>kynurenic Acid
  • 5,7-Dichloro<wbr/>kynurenic Acid
Cat No: 25533
Biochemicals - Ion Channel Modulation
Cayman

5,7-Dichlorokyneurenic acid (5,7-DCKA) is a derivative of kynurenic acid (Item No. 16792) and an NMDA receptor antagonist (Ki = 40 nM in a radioligand binding assay).{41941} It selectively inhibits glycine- over kainate-induced NMDA currents at 15 μM ...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 5,7-dichloro-4-hydroxy-2-quinolinecarboxylic acid
Product Overview:
5,7-Dichlorokyneurenic acid (5,7-DCKA) is a derivative of kynurenic acid (Item No. 16792) and an NMDA receptor antagonist (Ki = 40 nM in a radioligand binding assay).{41941} It selectively inhibits glycine- over kainate-induced NMDA currents at 15 μM in Xenopus oocytes expressing rat NMDA receptors. 5,7-DCKA reduces NMDA-induced neurotoxicity in primary rat cortical neurons by 55 to 90% when used at concentrations ranging from 1 to 10 μM. In vivo, 5,7-DCKA (0.97-97 nmol) reverses mechanical hyperalgesia in magnesium-deficient rats in a dose-dependent manner.{41942} It blocks the positive ionotropic effect, hypertension, and increase in myocardial oxygen demand induced by electrical stimulation of the paraventricular nucleus (PVN) in anesthetized rabbits.{41943} 5,7-DCKA also increases social interaction time in the social interaction test and time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, as well as disinhibits conflict responding in the Cook and Davidson conditioned conflict paradigm.{41944}
Size 5 mg
Shipping dry ice
CAS Number 131123-76-7
Molecular Formula C10H5Cl2NO3
SMILES ClC(C=C1Cl)=CC2=C1C(O)=CC(C(O)=O)=N2
Molecular Weight 258,1
Formulation A crystalline solid
Purity ≥98%
Custom Code 2903.99
UNSPSC code 12352100

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