Sinapic Acid

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Sinapic Acid

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Cat No: 25457

Biochemicals - Ox Stress Reagents

Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities.{39903} Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM).{39905} It scavenges 2,2-diphenyl-1-picrylhydraz...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(4-hydroxy-3,5-dimethoxyphenyl)-2-propenoic acid

Correlated keywords:

NSC59261 Synapitic SW-480 Escherichia Salmonella Staphylococcus MS

Product Overview:
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities.{39903} Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM).{39905} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively.{30137} Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold.{39906} It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively).{39907} In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil (Item No. 14252) and bicuculline (Item No. 11727).{39903} Sinapic acid is also commonly used as a matrix in protein mass spectrometry.{39904}

Size	1 g
Shipping	dry ice
CAS Number	530-59-6
Molecular Formula	C₁₁H₁₂O₅
SMILES	COC1=C(O)C(OC)=CC(/C=C/C(O)=O)=C1
Molecular Weight	224,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.