Verbascoside

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Verbascoside

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Cat No: 24965

Biochemicals - Kinase Inhibitors

Verbascoside is a natural phenylpropanoid glucoside that has been found in a variety of plants, including B. cordata, B. officinalis, and S. vulgaris, and has diverse biological activities.{42167,42168,42171,42169,42170} Verbascoside is a PKC inhibito...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-?-L-mannopyranosyl)-?-D-glucopyranoside, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]

Correlated keywords:

22323-52-0 27625-92-9 Distinctive Phytostem Lilac Kusaginin NSC603831 O'''-Desarabinosyllavandulifolioside A Russetinol Stereospermin TJC160 TJC-160 Brassavola Buddleja Strongylus Staphylococcus Escherichia PC-12 MGC-803 TNF? IL1? phenyl-propanoid borago

Product Overview:
Verbascoside is a natural phenylpropanoid glucoside that has been found in a variety of plants, including B. cordata, B. officinalis, and S. vulgaris, and has diverse biological activities.{42167,42168,42171,42169,42170} Verbascoside is a PKC inhibitor (IC50 = 25 μM).{42168} It inhibits the growth of Gram-positive and Gram-negative bacteria with MIC values ranging from 4 to 128 μg/ml including S. aureus and E. coli (MICs = 16 and 32 μg/ml, respectively).{42171} Verbascoside (0.1-10 μg/ml) dose-dependently reduces extracellular hydrogen peroxide concentrations and increases cell viability of PC12 cells following 1-methyl-4-phenylpyridinium ion (MPP+) administration to induce apoptosis and oxidative stress.{42167} It also inhibits the growth of MGC803 human gastric adenocarcinoma cells in a dose-dependent manner when used at concentrations ranging from 10 to 20 μM with maximal growth inhibition of 53%.{42169} In a rat model of colitis induced by 2,4-dinitrobenzene sulfonic acid (DNBS), verbascoside (0.2-2 mg/kg) reduces colon damage and the expression of TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS).{42170}

Size	1 mg
Shipping	dry ice
CAS Number	61276-17-3
Molecular Formula	C₂₉H₃₆O₁₅
SMILES	OC1=CC=C(/C=C/C(O[C@H]2[C@H](O[C@]3([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@@H](O)[C@H](OCCC4=CC=C(O)C(O)=C4)O[C@@H]2CO)=O)C=C1O
Molecular Weight	624,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.29
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.