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Fluvastatin-d6 (sodium salt)

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    Fluvastatin-d<sub>6</sub> (sodium salt)
  • Fluvastatin-d<sub>6</sub> (sodium salt)
Cat No: 25433
Biochemicals - Isotopically Labeled Standards
Cayman

Fluvastatin-d6 is intended for use as an internal standard for the quantification of fluvastatin (Item Nos. 10010334
10010337) by GC- or LC-MS. Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme).{15309,15312} It also i...

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: 1 mg

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (3R,5S,E)-7-(3-(4-fluorophenyl)-1-(propan-2-yl-1,1,1,3,3,3-d6)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoate, monosodium salt
Correlated keywords:
  • 2070009-35-5 2070009-34-4 93957-55-2 CYP450, CYP-2C9, 3-hydroxy-3-methylglutaryl β
Product Overview:
Fluvastatin-d6 is intended for use as an internal standard for the quantification of fluvastatin (Item Nos. 10010334
10010337) by GC- or LC-MS. Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme).{15309,15312} It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM).{37698} Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc- cystine-glutamate antiporter levels in human umbilical vein endothelial cells (HUVECs).{60825} In vivo, fluvastatin (2 mg/kg per day) decreases serum cholesterol, triglyceride, and phospholipid levels, the formation of thiobarbituric acid-reactive substances (TBARS), and vascular angiotensin-converting enzyme (ACE) activity in rabbits fed a high-cholesterol diet.{37699} It increases survival in a mouse model of myocardial infarction when administered at a dose of 10 mg/kg per day.{37700} Formulations containing fluvastatin have been used in the treatment of hypercholesterolemia and the prevention of cardiovascular disease.
Size 1 mg
Shipping dry ice
Molecular Formula C24H19D6FNO4 • Na
SMILES FC1=CC=C(C=C1)C2=C(/C=C/[C@@H](O)C[C@@H](O)CC([O-])=O)N(C(C([2H])([2H])[2H])C([2H])([2H])[2H])C3=C2C=CC=C3.[Na+]
Molecular Weight 439,5
Formulation A solid
Purity ≥95% (mixture of enantiomers)
Custom Code 3822.00
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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