Decursinol angelate

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Decursinol angelate

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Cat No: 25212

Biochemicals - Natural Products

Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A. gigas and has diverse biological activities.{42374,42375,42376,42377,42378} It inhibits the growth of K562, HL-60, KG-1, SK-BR-3, AGS, A549, HeLa, HepG2, and G...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2Z)-2-methyl-2-butenoic acid, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl ester

Correlated keywords:

Acutilobin pyrano-coumarin Archispirostreptus K-562 HL60 KG1 SKBR-3 SKBR3 A-549 Hep-G2 G361 MCF7 CYP-1A1 1A2 2D15 3A12 CYP1A2 PC-12 TNF? IL1? anti-nociceptive proinflammatory

Product Overview:
Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A. gigas and has diverse biological activities.{42374,42375,42376,42377,42378} It inhibits the growth of K562, HL-60, KG-1, SK-BR-3, AGS, A549, HeLa, HepG2, and G-361 cancer cells (ED50s = 24-56 μM) and decreases estrogen-stimulated growth of MCF-7 breast cancer cells in a concentration-dependent manner via decreased estrogen receptor α (ERα) protein levels and signaling activity.{42374,42375} Decursinol angelate (30 μM) activates PKC purified from rat brain.{42374} It selectively inhibits the cytochrome P450 (CYP) isoform CYP1A1/2 over CYP2D15 and CYP3A12 in canine liver microsomes (Kis = 67.56, 872.5, and 853.9 μM, respectively).{42376} Decursinol angelate (0.01-10 μM) reduces cytotoxicity and malondialdehyde (MDA) production induced by amyloid-β (23-35) (Aβ25-35) and increases superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in PC12 cells.{42377} In mice, decursinol angelate (200 mg/kg) has antinociceptive activity in the tail flick and hot plate tests and reduces acetic acid-induced writhing as well as decreases production of the pro-inflammatory cytokines TNF-α and IL-1β.{42378}

Size	1 mg
Shipping	dry ice
CAS Number	130848-06-5
Molecular Formula	C₁₉H₂₀O₅
SMILES	O=C1C=CC(C=C(C[C@H](OC(/C(C)=C\C)=O)C(C)(C)O2)C2=C3)=C3O1
Molecular Weight	328,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.20
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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