Umbelliferone

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Umbelliferone

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Cat No: 24665

Umbelliferone is a naturally occurring derivative and metabolite of coumarin that has diverse biological activities including antitumor, antioxidant, and antidepressant-like properties.{36671,36672,36673} It inhibits the growth of a variety of human c...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7-hydroxy-2H-1-benzopyran-2-one

Correlated keywords:

1391-97-5 1082662-10-9 hydrangine NSC19790 skimmetine umbelliferon anti-tumor anti-oxidant andti-depressant A-549 HCT-15 HL60 hydroxycoumarin hydroxylcoumarin oxycoumarin hydrangin skimmetin

Product Overview:
Umbelliferone is a naturally occurring derivative and metabolite of coumarin that has diverse biological activities including antitumor, antioxidant, and antidepressant-like properties.{36671,36672,36673} It inhibits the growth of a variety of human cell lines, including human ACHN renal, A549 lung, HCT15 colon, and LNCaP prostate carcinoma as well as Dakiki myeloma and HL-60 lymphoma cells, when used at concentrations ranging from 250 to 300 µg/ml.{36671} It also reversibly inhibits the production of prostate-specific androgen in LNCaP prostate cancer cells. Umbelliferone increases the production of reactive oxygen species (ROS), depolarizes the mitochondrial membrane, and halts the cell cycle at the G0/G1 phase in KB human oral carcinoma cells.{36672} In a rat model of depression induced by chronic unpredictable mild stress, umbelliferone (15 and 30 mg/kg) decreases immobility time in the forced swim test and increases sucrose consumption in the sucrose preference test, indicating antidepressant-like activity.{36673} Umbelliferone has been used as a ratiometric pH indicator that displays an emission maxima of 460 nm when solutions with a pH of less than six or greater than eight are excited at 330 and 370 nm, respectively.{36674}

Size	25 mg
Shipping	dry ice
CAS Number	93-35-6
Molecular Formula	C₉H₆O₃
SMILES	OC1=CC=C(C=CC(O2)=O)C2=C1
Molecular Weight	162,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.