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Cortistatin-14 (trifluoroacetate salt)

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    Cortistatin-<wbr/>14 (trifluoro<wbr/>acetate salt)
  • Cortistatin-<wbr/>14 (trifluoro<wbr/>acetate salt)
Cat No: 25074
Biochemicals - Peptides
Cayman

Cortistatin-14 is an endogenous neuropeptide agonist of somatostatin receptors (IC50s = 0.5-18.2 nM for human SST1-SST5 receptors expressed in CCL39 cells).{41724,38847} It is expressed in GABAergic interneurons in the cortex and hippocampus.{38847,38...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • L-prolyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-seryl-L-seryl-L-cysteinyl-L-lysine, cyclic (2?13)-disulfide, trifluoroacetate salt
Correlated keywords:
  • 186901-48-4 193829-96-8 937031-00-0 CCL 39 SST GHSR GH-4 Mrg-X2
Product Overview:
Cortistatin-14 is an endogenous neuropeptide agonist of somatostatin receptors (IC50s = 0.5-18.2 nM for human SST1-SST5 receptors expressed in CCL39 cells).{41724,38847} It is expressed in GABAergic interneurons in the cortex and hippocampus.{38847,38846} Cortistatin-14 competitively inhibits hexarelin binding to human growth hormone secretagogue receptors (GHS-R) in pituitary membranes (Ki = 0.54 μM).{41725} It also activates the human Mas-related gene receptor MrgX2 expressed in HEK293 cells leading to quantifiable GTP-γS binding to the G protein subunit Gαο (EC50 = 1.3 μM).{41726} Cortistatin-14 (0.01-1 μM), similarly to somatostatin-14 (Item No. 20809), completely inhibits thyrotropin-releasing hormone (TRH; Item No. 22917), and partially inhibits vasoactive intestinal peptide (VIP; Item No. 24996), stimulation of cAMP production in GH4 cells.{38846} In mice, cortistatin-14 dose-dependently (0.05-5 μg, i.c.v.) impairs memory retention when administered after foot shock avoidance training.{41727} Cortistatin-14 (40-320 μg/kg, s.c.) dose-dependently reduces growth hormone secretion in rats by greater than 80% after 10 minutes when administered at doses of 40-320 µg/kg.{41728}
Size 500 µg
Shipping dry ice
Molecular Formula C81H113N19O19S2 • XCF3COOH
SMILES [H]N1CCC[C@H]1C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C2=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CNC5=C4C=CC=C5)=O)CC6=CC=CC=C6)=O)CC7=CC=CC=C7)=O)=O)=O)CSS
Molecular Weight 1721
Formulation A lyophilized powder
Purity ≥95%
Custom Code 3504.00
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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ISO Guide 34:2009

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