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(Des-octanoyl)-Ghrelin (human) (trifluoroacetate salt)

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    (Des-<wbr/>octanoyl)-<wbr/>Ghrelin (human) (trifluoro<wbr/>acetate salt)
  • (Des-<wbr/>octanoyl)-<wbr/>Ghrelin (human) (trifluoro<wbr/>acetate salt)
Cat No: 25010
Biochemicals - Peptides
Cayman

Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).{7811,37391} Ghrelin requires an n-octanoyl modification at serine 3 for binding to the growth hormone (GH) secretag...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • glycyl-L-seryl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-?-glutamyl-L-histidyl-L-glutaminyl-L-arginyl-L-valyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-?-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine, trifluoroacetate salt
Correlated keywords:
  • 1338245-12-7 313951-59-6 GHSR MCF7 neuro desoctanoyl
Product Overview:
Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).{7811,37391} Ghrelin requires an n-octanoyl modification at serine 3 for binding to the growth hormone (GH) secretagogue receptor (GHS-R).{40067} (Des-octanoyl)-ghrelin (human) is a form of ghrelin that is lacking the octanoyl group at serine 3. It is located in the mouse stomach and is expressed at a lower level than octanoyl ghrelin.{41730} (Des-octanoyl)-ghrelin activates GHS-R by only 41% when used at 10 µM (IC50 = >10,000 nM; EC50 = >10,000 nM for increasing calcium accumulation).{41729} It induces bone marrow adipogenesis in rat models of growth hormone deficiency.{41731} (Des-octanoyl)-ghrelin also inhibits cell proliferation in estrogen-dependent MCF-7 breast cancer cells (EC50 = 0.81 µM) but induces proliferation of a somatotroph pituitary tumor cell line, an effect that can be blocked by MAPK, PKC, and tyrosine kinase inhibitors.{41732,41733}
Size 500 µg
Shipping dry ice
Molecular Formula C141H235N47O41 • XCF3COOH
SMILES [H]NCC(N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N1CCC[C@H]1C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC
Molecular Weight 3244,7
Formulation A lyophilized powder
Purity ≥95%
Custom Code 3504.00
UNSPSC code 12352100

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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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