Prolactin-Releasing Peptide (1-3

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Prolactin-Releasing Peptide (1-31) (human)

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Cat No: 24986

Biochemicals - Peptides

Prolactin releasing peptide (PrRP) is a 31-amino acid neuropeptide involved in regulating food intake.{43061} It is found in the hypothalamus, medulla, and pituitary in rats.{43062} PrRP is an agonist of the G-protein coupled receptors GPR10/hGR3 and ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-seryl-L-arginyl-L-threonyl-L-histidyl-L-arginyl-L-histidyl-L-seryl-L-methionyl-L-?-glutamyl-L-isoleucyl-L-arginyl-L-threonyl-L-prolyl-L-?-aspartyl-L-isoleucyl-L-asparaginyl-L-prolyl-L-alanyl-L-tryptophyl-L-tyrosyl-L-alanyl-L-seryl-L-arginylglycyl-L-isoleucyl-L-arginyl-L-prolyl-L-valylglycyl-L-arginyl-L-phenylalaninamide

Correlated keywords:

PrRP(1-31) PrRP31

Product Overview:
Prolactin releasing peptide (PrRP) is a 31-amino acid neuropeptide involved in regulating food intake.{43061} It is found in the hypothalamus, medulla, and pituitary in rats.{43062} PrRP is an agonist of the G-protein coupled receptors GPR10/hGR3 and neuropeptide FF receptor (hNPFF2; Kis = 1 and 19 nM, respectively).{43062,43063} It stimulates calcium mobilization in HEK293 cells expressing GPR10 (EC50 = 1.5 nM) and radiolabeled GTPγS binding to membrane homogenates from CHO cells transfected with hNPFF2 (EC50 = 240 nM).{43062,43063} PrRP (100 nM) increases the release of gonadotropin-releasing hormone (GnRH; Item No. 24762), vasoactive intestinal peptide (VIP; Item No. 24996), and galanin (Item No. 24456) from rat medial basal hypothalamic explants.{43064} It increases plasma levels of luteinizing hormone, follicle stimulating hormone, and testosterone in male rats when administered at an intracerebroventricular dose of 5 nmol.{43064} PrRP reduces food intake in fasted rats to 58.4, 53.4, and 55.4% of control levels when administered at doses of 1, 5, and 10 nmol, respectively.{43061}

Size	500 µg
Shipping	dry ice
CAS Number	215510-22-8
Molecular Formula	C₁₆₀H₂₅₂N₅₆O₄₂S
SMILES	NC([C@@H](NC([C@H](CCCNC(N)=N)NC(CNC([C@H](C(C)C)NC([C@@H]1CCCN1C([C@H](CCCNC(N)=N)NC([C@@]([C@H](CC)C)([H])NC(CNC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@H](CC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C
Molecular Weight	3664,2
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.