Lyso-Monosialoganglioside GM1 (a

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Lyso-Monosialoganglioside G_M1 (ammonium salt)

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Cat No: 24837

Biochemicals - Lipids

Lyso-monosialoganglioside GM1 (Lyso-GM1) is a form of ganglioside GM1 (Item No. 19579) that is lacking the fatty acyl group. Lyso-GM1 (2.5 µM) inhibits laminin-1-induced clustering of ganglioside GM1 in dorsal root ganglion (DRG) cells and also disrup...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2S,3R,4E)-2-amino-3-hydroxy-4-octadecenyl O-(N-acetyl-?-neuraminosyl)-(2?3)-O-[O-?-D-galactopyranosyl-(1?3)-2-(acetylamino)-2-deoxy-?-D-galactopyranosyl-(1?4)]-O-?-D-galactopyranosyl-(1?4)-?-D-glucopyranoside, monoammonium salt

Correlated keywords:

171483-40-2 94458-59-0 146196-34-1 GM-1 LysoGM1 G-M1 ?-1

Product Overview:
Lyso-monosialoganglioside GM1 (Lyso-GM1) is a form of ganglioside GM1 (Item No. 19579) that is lacking the fatty acyl group. Lyso-GM1 (2.5 µM) inhibits laminin-1-induced clustering of ganglioside GM1 in dorsal root ganglion (DRG) cells and also disrupts β1 integrin clustering and neurite outgrowth.{38938} It does not protect against glutamate-induced neurotoxicity in primary neuronal cultures.{38939} Elevated levels of lyso-GM1 have been found in the brain and spinal cord of patients with infantile- and late-infantile-type GM1-gangliosidosis, a neurodegenerative disorder characterized by deficiency of the enzyme β-galactosidase and accumulation of gangliosides.{38940} [Matreya, LLC. Catalog No. 1518]

Size	500 µg
Shipping	dry ice
Molecular Formula	C₅₅H₉₆N₃O₃₀ • NH₄
SMILES	N[C@H]([C@H](O)/C=C/CCCCCCCCCCCCC)CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O[C@@]2([H])[C@@H]([C@@]([C@H]([C@H](O2)CO)O[C@]3([H])O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O[C@@]4([H])[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O)O)CO)([H])O[C@]5(C([O-])=O)C[C@H](O)[C@@H]
Molecular Weight	1297,4
Formulation	A solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Lyso-Monosialoganglioside GM1 (ammonium salt)