Oxyntomodulin (human, mouse, rat

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Oxyntomodulin (human, mouse, rat) (trifluoroacetate salt)

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Cat No: 24758

Biochemicals - Peptides

Oxyntomodulin is a peptide hormone involved in regulation of food intake, energy expenditure, and glucose metabolism.{38941} It is produced in gut endocrine L-cells via post-translational processing of preproglucagon by prohormone convertase 1/3 follo...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-?-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-?-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-?-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonyl-L-lysyl-L-arginyl-L-asparaginyl-L-arginyl-L-asparaginyl-L-asparaginyl-L-isoleucyl-L-alanine, trifluoroacetate salt

Correlated keywords:

159002-68-3 OXM GLP1R GLP2R

Product Overview:
Oxyntomodulin is a peptide hormone involved in regulation of food intake, energy expenditure, and glucose metabolism.{38941} It is produced in gut endocrine L-cells via post-translational processing of preproglucagon by prohormone convertase 1/3 following nutrient uptake. Oxyntomodulin is an agonist of the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR; IC50s = 4.3 and 355 nM for rat GCGR and GLP-1R, respectively).{38942} It is selective for GCGR and GLP-1R over GLP-2R and glucose-dependent insulinotrophic peptide receptor (GIPR), as it stimulates cAMP formation in BHK cells expressing rat GCGR and GLP-1R when used at concentrations of 10 or 100 nM, but has no effect on cells expressing rat GLP-2R or GIPR at either concentration.{38944} Oxyntomodulin also stimulates cAMP formation in CHO cells expressing mouse GLP-1R and GCGR (EC50s = 2.5 and 6.2 nM, respectively).{38943} In vivo, oxyntomodulin reduces refeeding in 24-hour fasted rats when injected intracerebroventricularly or into the paraventricular nucleus (PVN) of the hypothalamus at doses of 3 and 1 nmol, respectively.{38945} Oxyntomodulin (50 nmol/kg twice per day for 7 days) reduces cumulative daily food intake and rate of body weight gain in rats.{38946}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₁₉₂H₂₉₅N₆₁O₆₀S • XCF₃COOH
SMILES	[H]N[C@H](C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(
Molecular Weight	4449,8
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.