GLP-2 (rat) (trifluoroacetate sa

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GLP-2 (rat) (trifluoroacetate salt)

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Cat No: 24757

Biochemicals - Peptides

Glucagon-like peptide 2 (GLP-2) is a gut peptide hormone antagonist of the GLP-2 receptor (GLP-2R; Ki = 60 pM).{41631} It increases cAMP levels in COS cells expressing GLP-2R with an EC50 value of 0.58 nM. GLP-2 is primarily produced by enteroendocrin...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-histidyl-L-alanyl-L-?-aspartylglycyl-L-seryl-L-phenylalanyl-L-seryl-L-?-aspartyl-L-?-glutamyl-L-methionyl-L-asparaginyl-L-threonyl-L-isoleucyl-L-leucyl-L-?-aspartyl-L-asparaginyl-L-leucyl-L-alanyl-L-threonyl-L-arginyl-L-?-aspartyl-L-phenylalanyl-L-isoleucyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-isoleucyl-L-glutaminyl-L-threonyl-L-lysyl-L-isoleucyl-L-threonyl-L-aspartic acid, trifluoroacetate salt

Correlated keywords:

223460-81-9 GLP2 GLP2R II 195262-56-7 TFA

Product Overview:
Glucagon-like peptide 2 (GLP-2) is a gut peptide hormone antagonist of the GLP-2 receptor (GLP-2R; Ki = 60 pM).{41631} It increases cAMP levels in COS cells expressing GLP-2R with an EC50 value of 0.58 nM. GLP-2 is primarily produced by enteroendocrine L cells of the small and large intestine but can also be found in the hypothalamus.{41631,41632} In vivo, GLP-2 (43.75 μg twice per day for 10 days) increases small bowel weight by 50% and increases villus height and crypt cell proliferation in the small intestine in mice.{39479} GLP-2 (10 μg per animal) reduces two-hour food intake in rats by 37% with no reduction in water intake.{41632} Secretion of GLP-2 in rats is stimulated by dietary carbohydrates, glucose, dextrin, and oils rich in polyunsaturated or monounsaturated fatty acids.{30374}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₁₆₆H₂₅₆N₄₄O₅₆S • XCF₃COOH
SMILES	OC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCCN)NC([C@@]([C@@H](C)O)([H])NC([C@H](CCC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([
Molecular Weight	3796,1
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.