Angiotensin II (5-8) (human, rat

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Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt)

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Cat No: 24739

Biochemicals - Peptides

Angiotensin II (5-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II (Item No. 17150).{40805} It inhibits renin (Item No. 10006217) release from rat kidney slices at a concentration of 50 μM and relaxes rat aorta pre...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine, 2,2,2-trifluoroacetate

Correlated keywords:

896715-73-4 Isoleucylhistidylprolylphenylalanine angII(5-8) 34233-50-6

Product Overview:
Angiotensin II (5-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II (Item No. 17150).{40805} It inhibits renin (Item No. 10006217) release from rat kidney slices at a concentration of 50 μM and relaxes rat aorta pre-contracted with phenylephrine (Item Nos. 17205
18619; EC50 = 0.28 μM).{40806,40805} In vivo, microinjection of angiotensin II (5-8) into the ventrolateral periaqueductal gray (vlPAG) of rats increases mean arterial pressure (MAP) and decreases heart rate (HR) by approximately 2.7- and 3-fold less, respectively, than angiotensin II.{40805} It increases the latency to withdrawal in a tail-flick test and the mechanical withdrawal threshold in an incision allodynia test in rats when administered at a dose of 0.2 nmol into the vlPAG. Angiotensin II (5-8) (0.4 nmol, vlPAG microinjection) reduces the number of entries and time spent in the open arms of the elevated plus maze and increases the mean startle amplitude, a measure of conditioned fear, in response to foot shock.{40807}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₂₆H₃₆N₆O₅ • XCF₃COOH
SMILES	C[C@@H](CC)[C@]([H])(N)C(N[C@@H](CC1=CNC=N1)C(N2[C@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)CCC2)=O)=O.OC(C(F)(F)F)=O
Molecular Weight	512,6
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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