BmrA (B. subtilis 168)

Proteins - More Proteins

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Cat No: 24734

Proteins - More Proteins

B. subtilis multidrug resistance ATP-binding cassette (ABC) transporter ATP-binding protein (BmrA), also known as YvcC, is a multidrug ABC transporter that is constitutively expressed in B. subtilis.{43005} It belongs to the ABC family and shares sequ...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

Bacillus Lactococcus Lactobacillus Bmr-A YvcC escheria K380A K380R

Product Overview:
B. subtilis multidrug resistance ATP-binding cassette (ABC) transporter ATP-binding protein (BmrA), also known as YvcC, is a multidrug ABC transporter that is constitutively expressed in B. subtilis.{43005} It belongs to the ABC family and shares sequence homology to mammalian P-glycoprotein (P-gp) and LmrA from L. lactis. BmrA is also homologous to HorA, a multidrug ABC transporter from L. brevis, Q8Y3T6 and Q8NXS2, putative transporters from Gram-positive bacteria, and MsbA, a lipid A transporter from E. coli. BmrA transports Hoechst, doxorubicin, and 7-aminoactinomycin D in an ATP-dependent manner. The ATPase mutants BmrAK380A and BmrAK380R are completely devoid of transport activity. Mutations in the intergenic region preceding bmrA increase BmrA mRNA expression and bmrA promoter activity in B. subtilis, which confer resistance to the antibiotic cervimycin C.{43006}

Size	10 µg
Shipping	dry ice
Formulation	50 mM Tris-Cl, pH 8.0, 100 mM NaCl, 0.01% DDM, and 10%glycerol
Purity	≥90% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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