Adenosine A2A Receptor (human re

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Adenosine A_2A Receptor (human recombinant)

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Cat No: 24730

Proteins - More Proteins

Adenosine A2A receptor (human recombinant) contains amino acids corresponding to the full length, wild-type, human A2A receptor, as well as N-terminal histidine and streptavidin tags with a TEV protease cleavage site. The A2A receptor is a G protein-c...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

wildtype G16 A-1 2A D-2 3 CB-1 mGluR-5 G-s olf 15/16 cAMP IP-3

Product Overview:
Adenosine A2A receptor (human recombinant) contains amino acids corresponding to the full length, wild-type, human A2A receptor, as well as N-terminal histidine and streptavidin tags with a TEV protease cleavage site. The A2A receptor is a G protein-coupled receptor (GPCR) that is activated by adenosine on presynaptic terminals to induce neurotransmitter release and on postsynaptic terminals to increase excitability.{38785} Signaling through the A2A receptor occurs through Gs, Golf, and G15/16 proteins to increase cyclic AMP or inositol-(1,4,5)-trisphosphate (IP3) activity.{38786} It is expressed in the brain on striatal-pallidal GABAergic neurons and in the olfactory bulb as well as other brain regions. It is also expressed in the periphery in organs and cells involved with immune function, including the spleen, thymus, leukocytes, and blood platelets as well as in the heart, lung, and blood vessels. A2A receptor activity induced by agonists has neurodegenerative effects, which has led to the development of A2A receptor antagonists, but has shown mixed effects on seizure activity in rodent models.{38785} The A2A receptor also plays a role in the regulation of enteric nervous system function, vasodilation of coronary arteries, and the immune response.{38787} In addition to signaling through the A2A receptor alone, it can form heteromers with other GPCRs, including adenosine A1, dopamine D2 and D3, cannabinoid CB1, and metabotropic glutamate receptor 5 (mGluR5).{38788,38789} The function of these receptors is influenced by the interaction, with the A2A receptor decreasing dopamine binding to the D2 receptor and mGluR5 potentiating the effects of the A2A receptor on adenylyl cyclase and MAPK signaling.{38788}

Size	10 µg
Shipping	dry ice
Formulation	50 mM HEPES, pH 7.4, 200 mM sodium chloride, and 0.05%/0.006% DDM/CHS
Purity	≥90% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352202

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

Adenosine A2A Receptor (human recombinant)