Tyr-?-CGRP (human) (trifluoroace

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Tyr-?-CGRP (human) (trifluoroacetate salt)

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Cat No: 24724

Biochemicals - Peptides

Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide (α-CGRP; Item No. 24405).{38807} It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respecti...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-L-tyrosyl-?-calcitonin gene-related peptide (human), trifluoroacetate salt

Correlated keywords:

Tyr0-CGRP [Tyr0]hCGRP AMY-1 3 COS7 L-6 Tyr0h?CGRP h?CGRP Tyr0CGRP hCGRP Tyr0?CGRP ?CGRP Tyr?CGRP

Product Overview:
Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide (α-CGRP; Item No. 24405).{38807} It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively).{38808} Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM).{38807} It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated right and left guinea pig atria (EC50s = 282 and 74 nM, respectively), and inhibits the twitch response in rat vas deferens (EC50 = 1.9 nM).{38809}

Size	500 µg
Shipping	dry ice
CAS Number	124756-98-5
Molecular Formula	C₁₇₂H₂₇₆N₅₂O₅₁S₂ • XCF₃COOH
SMILES	NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CO)NC(CNC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H]1CCCN1C([C@H](C(C)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CC(N)=O)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](C(C)C)NC(CNC(CNC([C@H](CO)NC([C@H](
Molecular Weight	3952,5
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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