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Calcitonin (human) (trifluoroacetate salt)

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    Calcitonin (human) (trifluoro<wbr/>acetate salt)
  • Calcitonin (human) (trifluoro<wbr/>acetate salt)
Cat No: 24409
Biochemicals - Peptides
Cayman

Calcitonin is a peptide hormone that lowers blood calcium levels and inhibits bone resorption.{38632} It belongs to the calcitonin family of peptides, which also includes amylin (Item No. 24274), calcitonin gene-related peptide (Item No. 24405), and a...

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: 1 mg

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • L-cysteinylglycyl-L-asparaginyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-methionyl-L-leucylglycyl-L-threonyl-L-tyrosyl-L-threonyl-L-glutaminyl-L-?-aspartyl-L-phenylalanyl-L-asparaginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-threonyl-L-phenylalanyl-L-prolyl-L-glutaminyl-L-threonyl-L-alanyl-L-isoleucylglycyl-L-valylglycyl-L-alanyl-L-prolinamide, cyclic (1?7)-disulfide, trifluoroacetate salt
Correlated keywords:
  • 24572-93-8 Ba47175 Cibacalcin HT-C2 HTC2 1-32 carcinoma CTR-2 RAMP-1 RAMP2 RAMP3 21215-62-3
Product Overview:
Calcitonin is a peptide hormone that lowers blood calcium levels and inhibits bone resorption.{38632} It belongs to the calcitonin family of peptides, which also includes amylin (Item No. 24274), calcitonin gene-related peptide (Item No. 24405), and adrenomedullin.{38633} The binding of human calcitonin to the calcitonin receptor (CTR) is modulated by receptor activity-modifying proteins (RAMPs).{38634} Calcitonin binds to CTR2 with IC50 values of 8.5, 6.2, 10.7, and 5.8 nM alone and with RAMP1, 2, or 3, respectively. It induces cAMP accumulation in rabbit aortic endothelial cells (RAECs) expressing CTR2 alone, or co-transfected with RAMP1, 2, or 3 (EC50s = 0.07, 0.08, 0.05, and 0.99 nM, respectively). In a bone resorption assay, human calcitonin inhibits pit formation in dentine by human giant cell tumor (GCT) cells, rabbit osteoclasts, and mouse osteoclasts (ID50s = 0.19, 0.032, and 0.21 nM, respectively).{38635}
Size 1 mg
Shipping dry ice
Molecular Formula C151H226N40O45S3 • XCF3COOH
SMILES NC([C@@H]1CCCN1C([C@@H](NC(CNC([C@H](C(C)C)NC(CNC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CCC(N)=O)NC([C@@H]2CCCN2C([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](
Molecular Weight 3417,9
Formulation A lyophilized powder
Purity ≥95%
Custom Code 3504.00
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

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