Osteocalcin (1-49) (human) (trif

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Osteocalcin (1-49) (human) (trifluoroacetate salt)

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Cat No: 24723

Biochemicals - Peptides

Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone.{39529} Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increa...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-tyrosyl-L-leucyl-L-tyrosyl-L-glutaminyl-L-tryptophyl-L-leucylglycyl-L-alanyl-L-prolyl-L-valyl-L-prolyl-L-tyrosyl-L-prolyl-L-?-aspartyl-L-prolyl-L-leucyl-4-carboxy-L-?-glutamyl-L-prolyl-L-arginyl-L-arginyl-4-carboxy-L-?-glutamyl-L-valyl-L-cysteinyl-4-carboxy-L-?-glutamyl-L-leucyl-L-asparaginyl-L-prolyl-L-?-aspartyl-L-cysteinyl-L-?-aspartyl-L-?-glutamyl-L-leucyl-L-alanyl-L-?-aspartyl-L-histidyl-L-isoleucylglycyl-L-phenylalanyl-L-glutaminyl-L-?-glutamyl-L-alanyl-L-tyrosyl-L-arginyl-L-arginyl-L-phenylalanyl-L-tyrosylglycyl-L-prolyl-L-valine cyclic (23?29)-disulfide, trifluoroacetate salt

Correlated keywords:

136461-80-8 noncollagenous MB231 MDAMB231 BGP ?-Carboxyglutamic Acid Containing Protein

Product Overview:
Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone.{39529} Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget's disease, and primary hyperparathyroidism.{39529,39530} Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in women.{39531} In vitro, osteocalcin induces chemotaxis of MDA-MB-231 breast cancer cells, human peripheral blood monocytes, and rat osteosarcoma cells with osteoblast-like characteristics.{39530} It is also expressed by vascular smooth muscle cells (VSMCs) displaying an osteoblast-like phenotype and has been positively associated with calcification of aortic tissue and heart valves in humans.{39532}

Size	100 µg
Shipping	dry ice
CAS Number	136461-80-8
Molecular Formula	C₂₆₉H₃₈₁N₆₇O₈₂S₂ • XCF₃COOH
SMILES	OC(C(C(O)=O)C[C@@H](C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CC(C(O)=O)C(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N2CCC[C@H]2C(N[C@H](C3=O)CC(O)=O)=O)=O)=O)=O)=O)CSSC[C@H](N3)C(N
Molecular Weight	5929,4
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

Technical File

MSDS

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