Neuromedin N (trifluoroacetate s

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Neuromedin N (trifluoroacetate salt)

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Cat No: 24707

Biochemicals - Peptides

Neuromedin N is a neurotensin-like hexapeptide that is synthesized from the same precursor as neurotensin.{39546} It is highly expressed in the brain but is also expressed in the gastrointestinal system and adrenal glands. It competitively inhibits ne...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-lysyl-L-isoleucyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine, trifluoroacetate salt

Correlated keywords:

92169-45-4 canine mouse dog human ox rat porcine

Product Overview:
Neuromedin N is a neurotensin-like hexapeptide that is synthesized from the same precursor as neurotensin.{39546} It is highly expressed in the brain but is also expressed in the gastrointestinal system and adrenal glands. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin (IC50s = 16.7 and 3 nM, respectively).{39542} Neuromedin N (10 pM) increases the phagocytic function of isolated murine peritoneal macrophages and increases chemotaxis two-fold compared with control, an effect that is blocked by the calcium-channel blocker ryanodine.{39543} It induces hypotension in rats and contraction of isolated guinea pig ileum.{39541} Neuromedin N (0.05 - 5 μg, i.c.v.) also elicits hypothermia in rats in a dose- and time-dependent manner, which is potentiated by bestatin (Item No. 21217).{39544} Neuromedin N is more potent than neurotensin in stimulating spontaneous motor activity and increasing dopamine metabolism in several brain regions following injection into the rat ventral tegmental area but is less potent than neurotensin when injected into the nucleus accumbens.{39545}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₃₈H₆₃N₇O₈ • XCF₃COOH
SMILES	[H]N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(N1CCC[C@H]1C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)=O.FC(F)(C(O)=O)F
Molecular Weight	745,9
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.