P005672 (hydrochloride)

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Cat No: 24685

P005672 is a tetracycline antibiotic that has activity against S. aureus RN450, S. pneumoniae 157E-strep, P. acnes ATCC 6919 and ATCC 11827, E. coli ATCC 25922 and MG 1655, and B. thetaiotaomicron, in vitro, when used at concentrations less than or eq...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(4S,4aS,5aR,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(methoxymethylamino)methyl]-1,11-dioxo-2-naphthacenecarboxamide, monohydrochloride

Correlated keywords:

1035654-66-0 P-005672 P5672 P-5672 anti-biotic Staphylococcus RN-450 Streptococcus Propionibacterium ATCC6919 ATCC11827 ATCC25922 MG1655 Bacteroides COS1 Chinese hamster ovary 3T-3 3-T3 3-T-3 157-E Escherichia WC3035

Product Overview:
P005672 is a tetracycline antibiotic that has activity against S. aureus RN450, S. pneumoniae 157E-strep, P. acnes ATCC 6919 and ATCC 11827, E. coli ATCC 25922 and MG 1655, and B. thetaiotaomicron, in vitro, when used at concentrations less than or equal to 8 μg/ml.{36678} It is non-cytotoxic to COS-1 and CHO cells (IC50 = >75 μg/ml for both) and is less phototoxic to 3T3 fibroblasts than doxycycline (Item No. 14422; IC50s = >25 and In vivo, P005672 increases survival in a mouse model of lethal S. aureus RN450 infection with a protective dose (PD50) value of 0.13 mg/kg. It also reduces paw edema in a rat model of carrageenan-induced inflammation.

Size	1 mg
Shipping	dry ice
CAS Number	1035979-44-2
Molecular Formula	C₂₄H₂₉N₃O₈ • HCl
SMILES	CN(OC)CC1=C2C(C(C3=C(O)[C@@](C(C(C(N)=O)=C(O)[C@H]4N(C)C)=O)(O)[C@@]4([H])C[C@]3([H])C2)=O)=C(O)C=C1.Cl
Molecular Weight	524
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.