?-Defensin-4 (human) (trifluoroa

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?-Defensin-4 (human) (trifluoroacetate salt)

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Cat No: 24579

Biochemicals - Anti-Infection

β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.{41472} It induces migration of monocytes in vitro when used at a concentration of 10 n...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-?-glutamyl-L-leucyl-L-?-aspartyl-L-arginyl-L-isoleucyl-L-cysteinylglycyl-L-tyrosylglycyl-L-threonyl-L-alanyl-L-arginyl-L-cysteinyl-L-arginyl-L-lysyl-L-lysyl-L-cysteinyl-L-arginyl-L-seryl-L-glutaminyl-L-?-glutamyl-L-tyrosyl-L-arginyl-L-isoleucylglycyl-L-arginyl-L-cysteinyl-L-prolyl-L-asparaginyl-L-threonyl-L-tyrosyl-L-alanyl-L-cysteinyl-L-cysteinyl-L-leucyl-L-arginyl-L-lysine, cyclic (6?33),(13?27),(17?34)-tris(disulfide), trifluoroacetate salt

Correlated keywords:

BD4 anti-microbial IL6 IL10 CXCL-10 CCL-2 MIP3? IL31 Escherichia Pseudomonas Staphylococcus Candida

Product Overview:
β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.{41472} It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils.{38795} β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.{38796} It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-4 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 μg/ml and by rat mast cells in vivo following a 500 ng intradermal dose.{38797} It also inhibits growth of E. coli, P. aeruginosa, and S. aureus with lethal concentration (LC) values of 5, 12, and 15 μM, respectively, of S. carnosus (MIC = 4.5 μg/ml), and of C. albicans with a minimum fungicidal concentration (MFC) value of 7.5 μM.{38795,38798}

Size	100 µg
Shipping	dry ice
CAS Number	370570-43-7
Molecular Formula	C₁₈₀H₂₉₅N₆₃O₅₂S₆ • XCF₃COOH
SMILES	[H]N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCC
Molecular Weight	4366,1
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.