Defensin HNP-1 (human) (trifluor

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Defensin HNP-1 (human) (trifluoroacetate salt)

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Cat No: 24572

Biochemicals - Anti-Infection

Defensin HNP-1 is a peptide secreted by polymorphonuclear leukocytes (PMNs) that has antimicrobial properties.{41472} It induces lysis of mammalian cells when used at concentrations of 25 and 100 μg/ml, respectively.{41473} It also completely inhibits...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-alanyl-L-cysteinyl-L-tyrosyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-prolyl-L-alanyl-L-cysteinyl-L-isoleucyl-L-alanylglycyl-L-?-glutamyl-L-arginyl-L-arginyl-L-tyrosylglycyl-L-threonyl-L-cysteinyl-L-isoleucyl-L-tyrosyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-tryptophyl-L-alanyl-L-phenylalanyl-L-cysteinyl-L-cysteine, cyclic (2?30),(4?19),(9?29)-tris(disulfide), trifluoroacetate salt

Correlated keywords:

99287-08-8 352284-12-9 HNP1 TSST1 staphylococcus HIV1 CD-4 IFN? anti-microbial NP1 NP-1 gp-120

Product Overview:
Defensin HNP-1 is a peptide secreted by polymorphonuclear leukocytes (PMNs) that has antimicrobial properties.{41472} It induces lysis of mammalian cells when used at concentrations of 25 and 100 μg/ml, respectively.{41473} It also completely inhibits secretion of the exotoxin superantigen TSS toxin-1 (TSST-1) from S. aureus when used at a concentration of 50 ng/ml and inhibits anthrax lethal toxin (IC50 = 148 nM).{41474,36484} HNP-1 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 23.2 and 12.9 nM, respectively).{41476} It induces lysis and leakage from liposomes composed of dipalmitoyl phosphatidylcholine (DPPC; Item No. 10009473) and dioleyl phosphatidylserine (DOPS).{36485} In vivo, HNP-1 (5 μg) increases interferon α (IFN-α) production by human plasmacytoid dendritic cells (pDCs) injected into nude mice.{36486}

Size	100 µg
Shipping	dry ice
Molecular Formula	C₁₅₀H₂₂₂N₄₄O₃₈S₆ • XCF₃COOH
SMILES	[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C2=O)=O
Molecular Weight	3442
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.